Vaage J
Cancer Res. 1978 Oct;38(10):3264-8.
The transplantation immunogenicity of spontaneous C3H/He mammary carcinomas was studied by means of the surgery-challenge procedure during serial in vivo passages in syngeneic mice. Reciprocal cross-sensitization and challenge tests between late transplant generations and early transplant generations (from liquid N2 storage) of the same tumors showed that factors responsible for transplantation resistance and factors causing stimulated tumor growth were present in the tumors at the same time as independent variables. The immunogenicity and the immunosensitivity of tumors were seen as dependent variables. The relative prominence of the characteristics of immunogenicity and growth stimulation changed with continuous in vivo passages. Transplantation immunogenicity was tumor specific in four of five tumors tested. Growth stimulation was, in each of four combinations tested, not tumor specific.
通过在同基因小鼠体内连续传代过程中的手术激发程序，研究了自发的C3H/He乳腺癌的移植免疫原性。对同一肿瘤的晚期移植代和早期移植代（来自液氮保存）进行相互交叉致敏和激发试验，结果表明，导致移植抗性的因素和引起肿瘤生长受刺激的因素在肿瘤中同时作为独立变量存在。肿瘤的免疫原性和免疫敏感性被视为因变量。免疫原性和生长刺激特性的相对突出程度随体内连续传代而变化。在所测试的5个肿瘤中，有4个肿瘤的移植免疫原性具有肿瘤特异性。在所测试的4种组合中，每种组合的生长刺激都不具有肿瘤特异性。
