Strahlman E R, Fine S L, Hillis A
Arch Ophthalmol. 1983 Aug;101(8):1191-3. doi: 10.1001/archopht.1983.01040020193003.
Patients with senile macular degeneration and exudative maculopathy in one eye and drusen in the second eye have a 3% to 7% risk per year of exudative maculopathy developing in the second eye during the first three years following their initial presentation. The risk is the same for patients with new vessel membranes or other types of exudative maculopathy in the first eye. Second eyes in which exudative changes develop are more likely to have larger numbers of drusen or greater confluence of drusen (or both) initially. The data from this study were analyzed using the Kaplan-Meier technique of estimation, a method (to our knowledge) not previously employed by other investigators. The demographic features of the overall study population, as well as the photographic features associated with increased risk of development of exudative maculopathy, were in agreement with those previously reported.
一只眼睛患有老年性黄斑变性和渗出性黄斑病变，另一只眼睛有玻璃膜疣的患者，在首次就诊后的头三年中，每年有3%至7%的风险在第二只眼睛发生渗出性黄斑病变。第一只眼睛患有新生血管膜或其他类型渗出性黄斑病变的患者风险相同。发生渗出性改变的第二只眼睛最初更有可能有大量玻璃膜疣或更大范围的玻璃膜疣融合（或两者皆有）。本研究的数据使用Kaplan-Meier估计技术进行分析，据我们所知，这是一种此前其他研究者未采用过的方法。总体研究人群的人口统计学特征，以及与渗出性黄斑病变发生风险增加相关的影像学特征，与此前报道的一致。
