Smiddy W E, Fine S L
Ophthalmology. 1984 Mar;91(3):271-7. doi: 10.1016/s0161-6420(84)34309-3.
Of 71 patients with only bilateral macular drusen, 8 eyes in 7 patients (9.9%) developed exudative maculopathy over an average follow-up of 4.3 years (14.5% cumulative risk). Severe visual loss due to exudative maculopathy occurred in 7 eyes of 6 patients (8.5%) for a 5-year cumulative risk of 12.7%. Features of the drusen were analyzed, but only the association with focal hyperpigmentation (P less than 0.001) and more than minimal drusen confluence (P less than 0.05) were statistically significant. Older patients had more severe drusen. Photostress test delay did not correlate with visual acuity, age, or severity of drusen.
在71例仅患有双侧黄斑玻璃膜疣的患者中，7例患者的8只眼（9.9%）在平均4.3年的随访期内发生了渗出性黄斑病变（累积风险为14.5%）。6例患者的7只眼（8.5%）因渗出性黄斑病变出现了严重视力丧失，5年累积风险为12.7%。对玻璃膜疣的特征进行了分析，但只有与局灶性色素沉着（P<0.001）以及玻璃膜疣融合程度超过轻度（P<0.05）之间的关联具有统计学意义。年龄较大的患者玻璃膜疣更为严重。光应激试验延迟与视力、年龄或玻璃膜疣严重程度无关。
