Weiss M
Biopharm Drug Dispos. 1983 Apr-Jun;4(2):151-6. doi: 10.1002/bdd.2510040207.
A unique definition of the apparent volume of distribution at steady-state is presented which is consistent with the realistic concept of blood concentration differences within the circulatory system. A physiologically based pharmacokinetic model consisting of eliminating and non-eliminating organs is used to predict the effect of drug elimination upon the steady-state distribution volume.
提出了稳态时表观分布容积的独特定义，该定义与循环系统内血药浓度差异的实际概念相一致。使用由消除器官和非消除器官组成的基于生理学的药代动力学模型来预测药物消除对稳态分布容积的影响。
