• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Definition of pharmacokinetic parameters: influence of the sampling site.

作者信息

Weiss M

出版信息

J Pharmacokinet Biopharm. 1984 Apr;12(2):167-75. doi: 10.1007/BF01059276.

DOI:10.1007/BF01059276
PMID:6491899
Abstract

Taking into account drug concentration differences within the circulatory system, a unique definition of each of the basic pharmacokinetic parameters, clearance (CL), steady-state volume of distribution (Vss), and mean disposition residence time (MDRT), is given which is generally valid for linear systems. The conventional relationship MDRT = Vss/CL holds theoretically only in the case of right atrial sampling following bolus intravenous injection. The values based on blood drug concentration from a peripheral venous sampling site are influenced by the pharmacokinetic properties of the lungs and the sampling tissue. Practically, the pulmonary extraction ratio and the mean transit time through the sampling tissue may thereby be of particular importance. Thus the effect of the sampling site on the pharmacokinetic parameters estimated by standard (classical) methods is quantitatively explained.

摘要

相似文献

1
Definition of pharmacokinetic parameters: influence of the sampling site.
J Pharmacokinet Biopharm. 1984 Apr;12(2):167-75. doi: 10.1007/BF01059276.
2
Moments of physiological transit time distributions and the time course of drug disposition in the body.生理转运时间分布的时刻以及药物在体内处置的时间进程。
J Math Biol. 1982;15(3):305-18. doi: 10.1007/BF00275690.
3
Modelling of initial distribution of drugs following intravenous bolus injection.
Eur J Clin Pharmacol. 1983;24(1):121-6. doi: 10.1007/BF00613938.
4
Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. I. Log-convex drug disposition curves.利用某些类停留时间分布的性质进行线性药代动力学的归纳。I. 对数凸性药物处置曲线。
J Pharmacokinet Biopharm. 1986 Dec;14(6):635-57. doi: 10.1007/BF01067968.
5
On the accuracy of estimation of basic pharmacokinetic parameters by the traditional noncompartmental equations and the prediction of the steady-state volume of distribution in obese patients based upon data derived from normal subjects.传统非房室方程估算基本药代动力学参数的准确性及基于正常受试者数据预测肥胖患者稳态分布容积。
J Pharm Sci. 2011 Jun;100(6):2482-97. doi: 10.1002/jps.22444. Epub 2011 Jan 19.
6
Steady-state distribution volume in physiologic multi-organ systems.生理多器官系统中的稳态分布容积。
Biopharm Drug Dispos. 1983 Apr-Jun;4(2):151-6. doi: 10.1002/bdd.2510040207.
7
On the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central elimination.基于中央消除假设对药物在体内的平均驻留时间及其分布容积计算的准确性
Xenobiotica. 2016;46(6):477-82. doi: 10.3109/00498254.2015.1089366. Epub 2015 Sep 25.
8
Pitfalls and valid approaches to pharmacokinetic analysis of mean concentration data following intravenous administration.
J Pharmacokinet Biopharm. 1980 Dec;8(6):539-52. doi: 10.1007/BF01060052.
9
Estimation of statistical moments and steady-state volume of distribution for a drug given by intravenous infusion.静脉输注给药时药物的统计矩及稳态分布容积的估算。
J Pharmacokinet Biopharm. 1982 Oct;10(5):551-8. doi: 10.1007/BF01059037.
10
A physiologically based pharmacokinetic model to predict the pharmacokinetics of highly protein-bound drugs and the impact of errors in plasma protein binding.一种基于生理学的药代动力学模型，用于预测高蛋白结合药物的药代动力学以及血浆蛋白结合误差的影响。
Biopharm Drug Dispos. 2016 Apr;37(3):123-41. doi: 10.1002/bdd.1996.

引用本文的文献

1
A recirculatory model with enterohepatic circulation by measuring portal and systemic blood concentration difference.一种通过测量门静脉和体循环血液浓度差异来建立肝肠循环的再循环模型。
J Pharmacokinet Pharmacodyn. 2003 Apr;30(2):119-44. doi: 10.1023/a:1024415730100.
2
Evaluation of capacity-limited first-pass effect through liver by three-points sampling in portal and hepatic veins and systemic artery.通过门静脉、肝静脉和体动脉的三点采样评估肝脏的容量限制首过效应。
Pharm Res. 2002 Jun;19(6):852-7. doi: 10.1023/a:1016165101921.
3
Use of gamma distributed residence times in pharmacokinetics.

本文引用的文献

1
Applications of a recirculatory stochastic pharmacokinetic model: limitations of compartmental models.循环随机药代动力学模型的应用：房室模型的局限性
J Pharmacokinet Biopharm. 1979 Apr;7(2):207-25. doi: 10.1007/BF01059739.
2
Arterial-venous plasma concentration differences of six drugs in the dog and rabbit after intravenous administration.
Res Commun Chem Pathol Pharmacol. 1981 Apr;32(1):27-39.
3
Arterial and venous blood sampling in pharmacokinetic studies: propranolol in rabbits and dogs.
Res Commun Chem Pathol Pharmacol. 1981 Jul;33(1):33-48.
4
伽马分布的驻留时间在药代动力学中的应用。
Eur J Clin Pharmacol. 1983;25(5):695-702. doi: 10.1007/BF00542361.
4
Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. I. Log-convex drug disposition curves.利用某些类停留时间分布的性质进行线性药代动力学的归纳。I. 对数凸性药物处置曲线。
J Pharmacokinet Biopharm. 1986 Dec;14(6):635-57. doi: 10.1007/BF01067968.
5
Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).药代动力学中的平均时间参数。定义、计算及临床意义（第二部分）
Clin Pharmacokinet. 1989 Dec;17(6):424-40. doi: 10.2165/00003088-198917060-00005.
6
The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II).药物浓度对采血部位显著依赖的现象及原理。在药代动力学、药效学、毒理学及治疗学中的意义（第二部分）
Clin Pharmacokinet. 1989 Oct;17(4):275-90. doi: 10.2165/00003088-198917040-00005.
7
Dynamics of drug distribution. I. Role of the second and third curve moments.
J Pharmacokinet Biopharm. 1992 Jun;20(3):253-78. doi: 10.1007/BF01062527.
8
The relevance of residence time theory to pharmacokinetics.
Eur J Clin Pharmacol. 1992;43(6):571-9. doi: 10.1007/BF02284953.
Residence time and accumulation of drugs in the body.
Int J Clin Pharmacol Ther Toxicol. 1981 Feb;19(2):82-5.
5
New physiologically based methods for calculating the apparent steady-state volume of distribution in pharmacokinetic studies.药代动力学研究中计算表观稳态分布容积的新的基于生理学的方法。
Int J Clin Pharmacol Ther Toxicol. 1982 Jun;20(6):255-8.
6
Effect of arterial-venous plasma concentration differences on the determination of mean residence time of drugs in the body.
Res Commun Chem Pathol Pharmacol. 1982 Jan;35(1):17-26.
7
Contribution of lungs to total body clearance: linear and nonlinear effects.肺对全身清除率的贡献：线性和非线性效应。
J Pharm Sci. 1982 Jan;71(1):66-70. doi: 10.1002/jps.2600710117.
8
Steady-state distribution volume in physiologic multi-organ systems.生理多器官系统中的稳态分布容积。
Biopharm Drug Dispos. 1983 Apr-Jun;4(2):151-6. doi: 10.1002/bdd.2510040207.
9
Hemodynamic influences upon the variance of disposition residence time distribution of drugs.血流动力学对药物处置停留时间分布方差的影响。
J Pharmacokinet Biopharm. 1983 Feb;11(1):63-75. doi: 10.1007/BF01061768.
10
The interpretation of mean transit time measurements for multiphase tissue systems.
J Theor Biol. 1973 May;39(2):447-75. doi: 10.1016/0022-5193(73)90111-2.