Braatz J A, Hua D T, Princler G L
Cancer Detect Prev. 1983;6(1-2):173-9.
A human lung tumor-associated antigen (LTA) previously purified from a primary lung tumor has been identified in the sera of lung cancer patients. Frequencies of LTA elevations in lung cancer were: adenocarcinoma, 60%; squamous cell carcinoma, 42%; large cell carcinoma, 17%; and small cell carcinoma, 19%; normals, 2%; benign lung disease, 0%; and non-lung malignancies, 13%. The antigen was also shown to be produced by seven of the eight human lung tumor cell lines that were examined. A preliminary small-scale purification was attempted on an extract from one of these lines, ChaGo, which yielded a smaller and more basic form of LTA but which possessed similar, if not identical, antigenic activities as primary tumor LTA.
一种先前从原发性肺肿瘤中纯化出来的人肺肿瘤相关抗原（LTA）已在肺癌患者的血清中被鉴定出来。肺癌中LTA升高的频率如下：腺癌为60%；鳞状细胞癌为42%；大细胞癌为17%；小细胞癌为19%；正常人中为2%；良性肺病患者中为0%；非肺恶性肿瘤患者中为13%。在所检测的8个人类肺肿瘤细胞系中，有7个也显示能产生该抗原。对其中一个细胞系ChaGo的提取物进行了初步小规模纯化，得到了一种分子量较小、碱性更强的LTA形式，但其抗原活性即便不完全相同，也与原发性肿瘤LTA相似。
