秋水仙碱减少大鼠腹膜粘连形成的比较研究

Reduction of peritoneal adhesion formation by colchicine: a comparative study in the rat.

作者信息

Granat M, Tur-Kaspa I, Zylber-Katz E, Schenker J G

出版信息

Fertil Steril. 1983 Sep;40(3):369-72. doi: 10.1016/s0015-0282(16)47302-4.

Abstract

Colchicine inhibits processes known to be involved in the pathogenesis of peritoneal adhesions. Daily administration of 50 micrograms of colchicine to 22 rats significantly diminished adhesion formation, as compared with dexamethasone-treated and untreated rats. Rats that developed at least three adhesions of grade 3 (scale 0 to 4) were strikingly less prevalent among the colchicine-treated animals than the untreated group (9.1% versus 40.9%, P less than 0.001). The double product of the number and grading of adhesions was significantly lower (P less than 0.05) in the colchicine group. Colchicine is more effective than dexamethasone in inhibiting adhesion formation in the rat.

摘要

秋水仙碱可抑制已知参与腹膜粘连发病机制的过程。与地塞米松治疗组和未治疗组的大鼠相比，每天给22只大鼠服用50微克秋水仙碱可显著减少粘连形成。在秋水仙碱治疗的动物中，形成至少三处3级粘连（0至4级评分）的大鼠明显比未治疗组少（9.1%对40.9%，P<0.001）。秋水仙碱组粘连数量与分级的乘积显著更低（P<0.05）。在抑制大鼠粘连形成方面，秋水仙碱比地塞米松更有效。