Marriott M S, Baird J R, Brammer K W, Faulkner J K, Halliwell G, Jevons S, Tarbit M H
Dermatologica. 1983;166 Suppl 1:1-7.
Tioconazole is a new imidazole antifungal agent with broad-spectrum activity. Its in vitro activity against common dermal pathogens is generally better than miconazole by a factor of 2-8. This activity is paralleled by good topical efficacy in a guinea pig dermatomycosis model. Pharmacokinetic studies in animals have demonstrated minimal systemic exposure following dermal application. Acute general pharmacology studies have shown that the compound is well tolerated in animals and unlikely to produce side-effects in man.
噻康唑是一种具有广谱活性的新型咪唑类抗真菌剂。它对常见皮肤病原体的体外活性通常比咪康唑强2至8倍。在豚鼠皮肤真菌病模型中，这种活性伴随着良好的局部疗效。动物体内药代动力学研究表明，经皮肤给药后全身暴露量极小。急性一般药理学研究表明，该化合物在动物中耐受性良好，在人体中不太可能产生副作用。
