N-二甲基亚硝胺诱导无白蛋白血症大鼠发生肾肿瘤的高发生率。
High incidence of renal tumors induced by N-dimethylnitrosamine in analbuminemic rats.
作者信息
Nagase S, Shumiya S, Emori T, Tanaka H
出版信息
Gan. 1983 Jun;74(3):317-8.
PMID:6884689
Abstract
Analbuminemic rats were found to be highly susceptible to induction of renal tumors. Thirty-nine weeks after N-dimethylnitrosamine administration, the incidence of renal tumors and average weight of kidneys (including tumors) were 76.0% and 10.8 +/- 4.1 g in male analbuminemic rats, respectively, whereas they were 37.1% and 3.5 +/- 0.1 g, respectively, in normal male SD rats.
摘要
无白蛋白血症大鼠被发现对肾肿瘤的诱发高度敏感。给予N-二甲基亚硝胺39周后，雄性无白蛋白血症大鼠的肾肿瘤发生率和肾脏（包括肿瘤）平均重量分别为76.0%和10.8±4.1克，而正常雄性SD大鼠的这两个数值分别为37.1%和3.5±0.1克。
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