Tanaka N, Hashimoto T, Matsui T, Ohida J, Ono M, Orita K
Gan. 1983 Jun;74(3):419-25.
The natural killer (NK) activity of peripheral blood lymphocytes of gastric cancer patients in all pathological stages from I to IV was less than that of healthy persons or patients with benign diseases. However, there was no significant difference in the antibody-dependent cellular cytotoxicity (ADCC) of cancer patients and healthy individuals, and the correlation between NK and ADCC activities was somewhat lower in cancer patients than in healthy persons. The peripheral blood lymphocytes from digestive tract cancer patients were divided into two fractions on the basis of low affinity erythrocyte (E)-rosette formation. The NK activity of the low affinity E-receptor negative fraction from cancer patients was significantly lower than that of the same fraction from healthy persons. The binding of lymphocytes with target cells is considered to be a first step of natural killing. In cancer patients, there was a decrease in the target-binding capacity of lymphocytes in both fractions. Therefore, the decreased NK activity of cancer patients appeared to be related to a reduced target-binding capacity.
胃癌患者从Ⅰ期到Ⅳ期所有病理阶段的外周血淋巴细胞自然杀伤（NK）活性均低于健康人或良性疾病患者。然而，癌症患者与健康个体的抗体依赖性细胞毒性（ADCC）没有显著差异，并且癌症患者中NK与ADCC活性之间的相关性略低于健康人。消化道癌症患者的外周血淋巴细胞根据低亲和力红细胞（E）-玫瑰花结形成分为两部分。癌症患者低亲和力E受体阴性部分的NK活性显著低于健康人相同部分的NK活性。淋巴细胞与靶细胞的结合被认为是自然杀伤的第一步。在癌症患者中，两个部分的淋巴细胞与靶细胞的结合能力均降低。因此，癌症患者NK活性降低似乎与靶细胞结合能力降低有关。
