Ono K, Imazono Y, Misawa T, Nishimura J, Nawata H
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Clin Immunol. 1995 Jul;15(4):210-4. doi: 10.1007/BF01541092.
Previously, we proposed a new analysis of natural killing activity, in which an individual effector/target cell ratio was employed for comparison according to the peripheral number of effector cells. In 51 patients with gastric cancer, the activity was studied using that modified analysis. Natural killing activity was activated in patients with early cancer, where tumor-cell invasion was restricted to the mucosa or the submucosa, even though in well-differentiated adenocarcinoma with invasion of the mucosa alone, the activity remained at the level of controls. In contrast, the activity in advanced cancer, where tumor cells infiltrated beyond the submucosa, came to be inactivated as the cancer progressed. These facts suggest that natural killing activity in patients with gastric cancer is closely associated with tumor invasion and that reactive activation of the activity against tumor is induced, at least, in some patients with early stage.
此前，我们提出了一种对自然杀伤活性的新分析方法，即根据效应细胞的外周数量采用个体效应细胞/靶细胞比率进行比较。在51例胃癌患者中，使用该改良分析方法研究了其活性。在早期癌症患者中，自然杀伤活性被激活，此时肿瘤细胞浸润局限于黏膜或黏膜下层，尽管在仅侵犯黏膜的高分化腺癌中，该活性仍维持在对照水平。相反，在晚期癌症中，肿瘤细胞浸润超出黏膜下层，随着癌症进展，该活性逐渐失活。这些事实表明，胃癌患者的自然杀伤活性与肿瘤浸润密切相关，并且至少在一些早期患者中诱导了针对肿瘤的活性反应性激活。
