Kapp D S, LiVolsi V A
Gynecol Oncol. 1983 Aug;16(1):19-30. doi: 10.1016/0090-8258(83)90004-5.
Stromal responses to tumor, usually characterized by the intensity of the lymphoplasmacytic infiltration, have been felt to be of prognostic significance in a wide range of neoplasms. Little attention has been focused on stromal reactions composed primarily of infiltration by eosinophilic leukocytes. We describe here the clinical and histopathological findings in 14 patients with invasive carcinoma of the uterine cervix in whom pronounced eosinophilic infiltration was observed in the stroma in the initial diagnostic biopsy material. These patients tended to have early stage disease, had associated increased lymphoplasmacytic stromal response, and were somewhat younger than the patients lacking this intense eosinophilic infiltration. A suggestion of improved survival was noted in patients with intense stromal eosinophilia treated primarily with radiation therapy.
基质对肿瘤的反应通常以淋巴浆细胞浸润的强度为特征，在多种肿瘤中被认为具有预后意义。很少有研究关注主要由嗜酸性粒细胞浸润组成的基质反应。我们在此描述了14例子宫颈浸润癌患者的临床和组织病理学发现，这些患者在初始诊断活检材料的基质中观察到明显的嗜酸性浸润。这些患者往往处于疾病早期，伴有淋巴浆细胞基质反应增加，并且比缺乏这种强烈嗜酸性浸润的患者年龄稍小。在主要接受放射治疗的基质嗜酸性粒细胞增多的患者中，观察到生存改善的迹象。
