Bostrom S G, Hart W R
Cancer. 1981 Jun 15;47(12):2887-93. doi: 10.1002/1097-0142(19810615)47:12<2887::aid-cncr2820471223>3.0.co;2-3.
Stromal inflammatory reactions dominated by eosinophilic leukocytes have been reported in a small number of invasive cervical carcinomas. The clinicopathologic features of six patients whose cervical carcinomas were accompanied by an intense infiltrate of eosinophils were analyzed. Several patients also manifested an eosinophilia of peripheral blood and regional lymph nodes. The cervical carcinoma cells were regarded as the most likely cause of the tissue and blood eosinophilia since other etiologic factors were not identified. Eosinotactic and eosinopoietic substances probably either were produced directly by the carcinoma cells or resulted from immunologic interactions of inflammatory lymphoid cells and mast cells with antigens of the tumors. While stromal eosinophilia alone may not be of prognostic significance, eosinophilia of the peripheral blood may be an adverse sign in some patients with cervical carcinoma.
少数浸润性宫颈癌中曾有以嗜酸性白细胞为主的基质炎症反应的报道。分析了6例宫颈癌伴有大量嗜酸性粒细胞浸润患者的临床病理特征。部分患者外周血和区域淋巴结也出现嗜酸性粒细胞增多。由于未发现其他病因，宫颈癌细胞被认为是组织和血液嗜酸性粒细胞增多最可能的原因。嗜酸性粒细胞趋化因子和嗜酸性粒细胞生成物质可能是由癌细胞直接产生的，或者是炎症性淋巴细胞和肥大细胞与肿瘤抗原发生免疫相互作用的结果。虽然单纯的基质嗜酸性粒细胞增多可能不具有预后意义，但外周血嗜酸性粒细胞增多对某些宫颈癌患者可能是一个不良征象。
