Mills S E, Austin M B, Randall M E
Am J Surg Pathol. 1985 Dec;9(12):883-9. doi: 10.1097/00000478-198512000-00004.
Two cytologically uniform, light-microscopically undifferentiated carcinomas of the uterine cervix are described. The tumors were morphologically identical to nasopharyngeal lymphoepitheliomas, including the presence of an intense inflammatory stromal reaction with prominent lymphocytes, eosinophils, and plasma cells. One neoplasm occurred in a 29-year-old, was clinically Stage IB, and was successfully treated with radiation therapy, with 10-year disease-free follow-up. The second tumor developed in a 58-year-old, was clinically Stage IIIB, and resulted in the patient's death 17 months after diagnosis. When the malignant cells in these tumors were widely separated by inflammation, they could be easily overlooked or confused with lymphoproliferative lesions. Immunocytochemical stains were performed on one case. The tumor cells stained strongly for keratin and epithelial membrane antigen, but were negative for leukocyte common antigen, verifying their epithelial nature. Until the biologic behavior of this cytologically distinctive tumor is more clearly understood, it should be separated from conventional cervical cancers with prominent stromal inflammation.
本文描述了两例宫颈细胞学表现一致、光镜下未分化的癌。这些肿瘤在形态上与鼻咽淋巴上皮瘤相同，包括存在伴有显著淋巴细胞、嗜酸性粒细胞和浆细胞的强烈炎症性间质反应。其中一例肿瘤发生于一名29岁女性，临床分期为IB期，经放射治疗成功治愈，随访10年无疾病复发。第二例肿瘤发生于一名58岁女性，临床分期为IIIB期，诊断后17个月导致患者死亡。当这些肿瘤中的恶性细胞被炎症广泛分隔时，它们很容易被忽视或与淋巴增殖性病变混淆。对其中一例进行了免疫细胞化学染色。肿瘤细胞对角蛋白和上皮膜抗原呈强阳性染色，但对白细胞共同抗原呈阴性染色，证实了其上皮性质。在对这种细胞学特征明显的肿瘤的生物学行为有更清楚的了解之前，应将其与伴有显著间质炎症的传统宫颈癌区分开来。
