Olinescu A, Hristescu S, Sjöquist J, Gheţie V
Immunol Lett. 1983 Apr;6(4):231-7. doi: 10.1016/0165-2478(83)90010-x.
Various preparations of Staphylococci protein A (SpA) obtained either from strain Cowan-1 or strain A676 and two SpA low molecular fragments (AB and B) were tested for their mitogenic and NK-stimulating activity on human peripheral blood lymphocytes. Though all 4 preparations of SpA and both of its fragments were able to react with human IgG, apparently with both Fab and Fc sites of IgG, only the SpA preparations derived from A676 strain triggered the proliferation and potentiated the NK-activity of treated cells. The parallelism between the mitogenic and NK-stimulating activities of SpA suggests that both activities might be under the control of the same portion of the SpA molecule located in the non-immunoglobulin binding region of the molecule.
对从考恩-1菌株或A676菌株获得的多种葡萄球菌蛋白A（SpA）制剂以及两个SpA低分子片段（AB和B）进行了测试，以检测它们对人外周血淋巴细胞的促有丝分裂活性和自然杀伤细胞（NK）刺激活性。尽管所有4种SpA制剂及其两个片段都能够与人IgG发生反应，显然是与IgG的Fab和Fc位点都发生反应，但只有源自A676菌株的SpA制剂能触发处理后细胞的增殖并增强其NK活性。SpA的促有丝分裂活性和NK刺激活性之间的平行关系表明，这两种活性可能受位于该分子非免疫球蛋白结合区域的SpA分子同一部分的控制。
