Chen L H, Thacker R R
Int J Vitam Nutr Res. 1983;53(2):138-42.
Weanling male Sprague Dawley rats were fed a vitamin E-deficient basal diet with or without supplementation of 100 IU/kg diet of vitamin E for 12 months. The isozyme pattern of creatine kinase (CPK) in plasma was determined electrophoretically. The CPK activity of the plasma of control rats averaged 43.2 nmoles/min/ml and was predominantly CPK3 isozyme, while that of the plasma of vitamin E-deficient rats averaged 100.8 nmoles/min/ml and consisted of CPK2 and CPK3 isozymes. The results suggest that the increased CPK activity in the plasma of vitamin E-deficient rats may originate from heart and skeletal muscle degeneration.
将断乳雄性斯普拉格-道利大鼠喂食缺乏维生素E的基础饮食，添加或不添加100 IU/kg饮食的维生素E，持续12个月。通过电泳法测定血浆中肌酸激酶（CPK）的同工酶模式。对照大鼠血浆的CPK活性平均为43.2纳摩尔/分钟/毫升，主要是CPK3同工酶，而缺乏维生素E的大鼠血浆的CPK活性平均为100.8纳摩尔/分钟/毫升，由CPK2和CPK3同工酶组成。结果表明，缺乏维生素E的大鼠血浆中CPK活性增加可能源于心脏和骨骼肌变性。
