Maekawa A, Onodera H, Tanigawa H, Furuta K, Kanno J, Ogiu T, Hayashi Y
Division of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan.
Environ Health Perspect. 1987 Aug;73:115-23. doi: 10.1289/ehp.8773115.
Spontaneous ovarian tumors are very rare in ACI, Wistar, F344 and Donryu rats; the few neoplasms found are of the granulosa/theca cell type. Ovarian tumors were also rare in these strains of rats when given high doses of N-alkyl-N-nitrosoureas continuously in the drinking water for their life-span; however, relatively high incidences of Sertoli cell tumors or Sertoli cell tumors mixed with granulosa cell tumors were induced in Donryu rats after administration of either a 400 ppm N-ethyl-N-nitrosourea solution in the drinking water for 4 weeks or as a single dose of 200 mg N-propyl-N-nitrosourea per kg body weight by stomach tube. Typical Sertoli cell tumors consisted of solid areas showing tubular formation. The tubules were lined by tall, columnar cells, with abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented, round nuclei, resembling seminiferous tubules in the testes. In some cases, Sertoli cell tumor elements were found mixed with areas of granulosa cells. The induction of ovarian Sertoli cell tumors in Donryu rats by low doses of nitrosoureas may provide a useful model for these tumors in man.
自发性卵巢肿瘤在ACI、Wistar、F344和东ryu大鼠中非常罕见；发现的少数肿瘤为颗粒/卵泡膜细胞类型。当在这些品系的大鼠一生中持续给予高剂量的N-烷基-N-亚硝基脲时，卵巢肿瘤也很罕见；然而，在东ryu大鼠中，饮用含400 ppm N-乙基-N-亚硝基脲溶液4周或经胃管给予每千克体重200 mg N-丙基-N-亚硝基脲单剂量后，诱导出相对较高发生率的支持细胞瘤或支持细胞瘤与颗粒细胞瘤混合的肿瘤。典型的支持细胞瘤由显示管状形成的实性区域组成。这些小管内衬高柱状细胞，细胞质丰富、轻度嗜酸性、常呈空泡状，细胞核呈圆形且位于基部，类似于睾丸中的生精小管。在某些情况下，发现支持细胞瘤成分与颗粒细胞区域混合。低剂量亚硝基脲诱导东ryu大鼠卵巢支持细胞瘤可能为人类这些肿瘤提供一个有用的模型。
