Lobato R D, Madrid J L, Fatela L V, Rivas J J, Reig E, Lamas E
J Neurosurg. 1983 Oct;59(4):627-33. doi: 10.3171/jns.1983.59.4.0627.
Satisfactory control of intractable pain has been achieved in 17 terminal cancer patients by injecting small doses of morphine into the lateral cerebral ventricle via an Ommaya reservoir. Pain relief together with a favorable behavioral response was obtained without interference with other sensory modalities, noticeable physical changes, or side effects annoying or severe enough for the patient to discontinue therapy. Eleven patients developed tolerance, but this phenomenon does not require withdrawal of treatment. Chronic intraventricular morphine administration can be safely performed on an outpatient basis, and results in control of midline, bilateral, and diffuse pain associated with orofacial and disseminated cancer. However, this experience is preliminary and further clinical trials are needed to determine the place of this method of therapy in the management of chronic pain.
通过经奥马亚贮液器向大脑侧脑室注射小剂量吗啡，17例晚期癌症患者的顽固性疼痛得到了满意控制。疼痛缓解的同时伴有良好的行为反应，且未干扰其他感觉方式，未出现明显的身体变化，也没有严重到足以让患者停止治疗的恼人副作用。11例患者出现了耐受性，但这种现象并不需要停止治疗。慢性脑室内注射吗啡可在门诊安全进行，并能控制与口腔面部和播散性癌症相关的中线、双侧和弥漫性疼痛。然而，这只是初步经验，还需要进一步的临床试验来确定这种治疗方法在慢性疼痛管理中的地位。
