Mertsola J, Ruuskanen O, Eerola E, Viljanen M K
J Pediatr. 1983 Sep;103(3):359-63. doi: 10.1016/s0022-3476(83)80403-x.
Intrafamilial spread of pertussis was evaluated in 21 families (97 individuals) of patients with whooping cough diagnosed by culture or by ELISA serology. During follow-up (average six months), an infectivity rate of 83% was established by an ELISA within these families. However, 46% of the secondary cases were asymptomatic. Most of the asymptomatic cases were in adults or vaccinated children. Unvaccinated infants had classic whooping cough and were exposed to pertussis by their vaccinated siblings or parents. The incidence of classic symptoms of pertussis decreased with age, and atypical pertussis was usually culture negative but rapidly diagnosed by measurement of the IgM- and IgA-class antibodies by ELISA.
在通过培养或ELISA血清学诊断为百日咳的患者的21个家庭（97人）中评估了百日咳的家庭内传播情况。在随访期间（平均6个月），通过ELISA确定这些家庭中的感染率为83%。然而，46%的二代病例无症状。大多数无症状病例为成人或接种过疫苗的儿童。未接种疫苗的婴儿患典型百日咳，并通过接种过疫苗的兄弟姐妹或父母接触百日咳。百日咳典型症状的发病率随年龄降低，非典型百日咳通常培养阴性，但通过ELISA检测IgM和IgA类抗体可迅速诊断。
