Zakirov U B, Kadyrov U Z, Mirtursunova S Z, Guliamov T D
Farmakol Toksikol. 1976 Jun-Aug;39(4):455-8.
Experiments conducted on albino rats poisoned with different doses of hexachlorocyclohexane (HCCH) demonstrated that large doses of this compound (1/3 DL50) following their single introduction were capable of inhibiting the secretion of the amylase, lipase, and proteases of the pancreas. Of a prolonged action of relatively small doses of HCCH (1/20 and 1/50 DL50) is characteristic an initial inhibition and subsequent stimulation of the exosecretory function of the pancreas. A definite inverse relation between the amount of the introduced HCCH dose and the duration of the pancreatic inhibition period was noted.
对用不同剂量的六氯环己烷（HCCH）中毒的白化大鼠进行的实验表明，单次引入大剂量的这种化合物（1/3半数致死剂量）能够抑制胰腺淀粉酶、脂肪酶和蛋白酶的分泌。相对小剂量的HCCH（1/20和1/50半数致死剂量）具有延长作用，其特征是对胰腺外分泌功能的初始抑制和随后的刺激。注意到引入的HCCH剂量与胰腺抑制期的持续时间之间存在一定的反比关系。
