Zakirov U B, Kadyrov U Z, Mirtursunova S, Guliamov T
Farmakol Toksikol. 1976 Jan-Feb;39(1):56-9.
The influence of different doses of tetramethylthiuramine sulphide (TMTDS) on the activity of the amylase, lipase and proteases in the pancreatic homogenate and the small intestine contents of albino rats was studied. Six hours after a single administration of the compound in a dose of 1/3 DL50 a 2--2.5-fold drop of the enzymatic activity in the chyme was observed and 24 hours thereafter it was inhibited in the glandular tissue as well. During the first months of a lenghty introduction of relatively small doses of TMTDS (1/20 and 1/50 DL50) a depression of the exosecretory function of the pancreas with its subsequent restoration at the 4--6th month was noted. Atropinization of the animals failed to prevent the inhibitory action of the compound on the secretion of pancreatic enzymes, this pointing to a direct effect of TMTDS on the acinal cells or to prevailing distrubances of humoral mechanisms regulating the activity of the glands.
研究了不同剂量的四甲基秋兰姆化二硫（TMTDS）对白化大鼠胰腺匀浆和小肠内容物中淀粉酶、脂肪酶及蛋白酶活性的影响。单次给予剂量为1/3 DL50的该化合物6小时后，观察到食糜中酶活性下降2至2.5倍，24小时后腺组织中的酶活性也受到抑制。在长时间给予相对小剂量的TMTDS（1/20和1/50 DL50）的最初几个月里，观察到胰腺外分泌功能受到抑制，随后在第4至6个月恢复。动物的阿托品化未能阻止该化合物对胰腺酶分泌的抑制作用，这表明TMTDS对腺泡细胞有直接作用，或表明调节腺体活性的体液机制存在主要紊乱。
