Southall D P, Levitt G A, Richards J M, Jones R A, Kong C, Farndon P A, Alexander J R, Wilson A J
Pediatrics. 1983 Oct;72(4):541-51.
Twenty-four-hour tape recordings of ECG and breathing movement were made on 14 preterm infants with prolonged apneic episodes. Despite apnea monitoring systems, 136/203 (67%) apneic episodes greater than or equal to 20 seconds in duration, including 19 episodes greater than or equal to 50 seconds in duration, were not recorded by nursing staff. Of 120 apneic episodes greater than or equal to 30 seconds, 100 (89%) were accompanied by bradycardia less than or equal to 100 beats per minute. Episodes of more marked bradycardia (less than or equal to 80 beats per minute and up to seven minutes in duration) occurred without cessation of breathing movement in 10/14 infants studied. Treatment with theophylline or aminophylline was associated with a reduction in the number of episodes of apnea greater than or equal to 20 seconds accompanied by bradycardia less than or equal to 80 beats per minute (P less than .001). Many prolonged episodes of apnea and bradycardia are going unnoticed in neonatal intensive care units. Further studies are required to investigate and overcome the causes of these failures.
对14例有长时间呼吸暂停发作的早产儿进行了24小时心电图和呼吸运动记录。尽管有呼吸暂停监测系统，但护理人员未记录到136/203（67%）持续时间大于或等于20秒的呼吸暂停发作，其中包括19次持续时间大于或等于50秒的发作。在120次持续时间大于或等于30秒的呼吸暂停发作中，100次（89%）伴有心率低于或等于每分钟100次的心动过缓。在10/14例研究的婴儿中，出现了更明显的心动过缓（低于或等于每分钟80次，持续时间长达7分钟），且呼吸运动未停止。使用茶碱或氨茶碱治疗与大于或等于20秒且伴有低于或等于每分钟80次心动过缓的呼吸暂停发作次数减少相关（P<0.001）。在新生儿重症监护病房中，许多长时间的呼吸暂停和心动过缓发作未被注意到。需要进一步研究来调查并克服这些未能监测到的原因。
