Chung R S, Safaie-Shirazi S
Proc Soc Exp Biol Med. 1983 Sep;173(4):620-5. doi: 10.3181/00379727-173-41696.
The canine pancreatic blood flow was studied after iv secretin (resulting in a plasma level commensurate with the postcibal state), and also after larger iv doses and after duodenal acidification. We found that blood flow was unaffected by "physiological" doses of secretin, or by perfusion of duodenum at a pH as low as 2.0, but increased by bolus doses (0.5 CU/kg and above), and by acidification to pH 1.4. Anesthesia does not affect the blood flow response although the bicarbonate response appeared to be blunted under anesthesia. We conclude that increase in pancreatic blood flow is not a physiological effect of secretin.
研究了静脉注射促胰液素后（使血浆水平与餐后状态相当）犬的胰腺血流情况，还研究了静脉注射更大剂量促胰液素以及十二指肠酸化后的情况。我们发现，“生理”剂量的促胰液素或十二指肠灌注至pH低至2.0时，血流不受影响，但推注剂量（0.5 CU/kg及以上）以及酸化至pH 1.4时，血流会增加。麻醉不影响血流反应，尽管在麻醉状态下碳酸氢盐反应似乎减弱。我们得出结论，胰腺血流增加不是促胰液素的生理效应。
