德尔吗啡及其N端序列的合成与药理活性
Synthesis and pharmacological activity of dermorphin and its N-terminal sequences.
作者信息
Salvadori S, Sarto G, Tomatis R
出版信息
Int J Pept Protein Res. 1982 May;19(5):536-42. doi: 10.1111/j.1399-3011.1982.tb02639.x.
Abstract
H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (demorphin), and opiate-like peptide, and tri-, tetra-, penta- and hexapeptide-amide analogs, were synthesized by conventional methods in solution, to determine the minimum peptide chain-length, required for analgesic activity.
摘要
通过溶液中的常规方法合成了H-酪氨酸-D-丙氨酸-苯丙氨酸-甘氨酸-酪氨酸-脯氨酸-丝氨酸-酰胺（地吗啡）、一种阿片样肽以及三肽、四肽、五肽和六肽酰胺类似物，以确定产生镇痛活性所需的最短肽链长度。
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