新型阿片样肽类物质——皮啡肽的合成
Synthesis of dermorphins, a new class of opiate-like peptides.
作者信息
de Castiglione R, Faoro F, Perseo G, Piani S
出版信息
Int J Pept Protein Res. 1981 Feb;17(2):263-72. doi: 10.1111/j.1399-3011.1981.tb01991.x.
Abstract
H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (dermorphin) and H-Tyr-D-Ala-Phe-Gly-Tyr-Hyp-Ser-NH2 (Hyp6-dermorphin) are two members of a new class of opiate-like peptides present in the amphibian skin. Their syntheses and that of the L-Ala2-analogue of dermorphin have been accomplished by conventional segment condensation in solution.
摘要
H-酪氨酰-D-丙氨酰-苯丙氨酰-甘氨酰-酪氨酰-脯氨酰-丝氨酰胺（皮啡肽）和H-酪氨酰-D-丙氨酰-苯丙氨酰-甘氨酰-酪氨酰-高脯氨酰-丝氨酰胺（高脯氨酸6-皮啡肽）是存在于两栖动物皮肤中的一类新型类阿片肽的两个成员。它们以及皮啡肽的L-丙氨酸2-类似物的合成已通过溶液中的传统片段缩合完成。
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