Hill L G, Means L W
Pharmacol Biochem Behav. 1982 Jul;17(1):125-9. doi: 10.1016/0091-3057(82)90273-8.
Nine Holtzman rats were maintained from days 5-18 of pregnancy on a liquid diet of which ethanol constituted 35% of the calories while nine rats were pair-fed an isocaloric diet that had maltose-dextrin substituted for the ethanol. Beginning on day 19 of gestation and continuing for five days the dams in both groups were given a choice among lab chow, water, and their respective liquid diets. During the five days of choice, alcohol consumption dropped to approximately 20% of pre-choice levels. The dams and pups showed no behavioural withdrawal symptoms. While the alcohol-treated litters showed greater variability in litter size and more pup deaths during nursing, the maternal behaviour of the alcohol dams was essentially normal, with only their pup protectiveness being rated lower than that of the control dams.
9只霍尔茨曼大鼠在妊娠第5至18天维持液体饮食，其中乙醇占热量的35%，而另外9只大鼠则成对喂食等热量饮食，用麦芽糖糊精替代乙醇。从妊娠第19天开始并持续5天，两组的母鼠可以在实验室饲料、水和各自的液体饮食之间进行选择。在选择的5天里，酒精摄入量降至选择前水平的约20%。母鼠和幼崽均未出现行为戒断症状。虽然经酒精处理的窝仔在窝仔大小上表现出更大的变异性，且在哺乳期间幼崽死亡更多，但酒精处理组母鼠的母性行为基本正常，只是它们对幼崽的保护程度被评为低于对照组母鼠。
