Mattsson J, Lilja J, Peterson H I
Eur J Cancer Clin Oncol. 1982 Jul;18(7):677-84. doi: 10.1016/0277-5379(82)90214-0.
The influence of vasoactive drugs, including noradrenaline, isoprenaline and papaverine, on the local blood flow of a transplantable rat sarcoma and of normal subcutaneous tissue of the rat was studied by local [133 xenon] clearance technique. The microvascular bed of the tumour was studied by transmission electron microscopy (TEM). Vessels with one layer of contractile cells were found in the tumour vascular bed by TEM. A significant reduction of both tumour and normal subcutaneous tissue blood flow was found after administration of noradrenaline added to the injected xenon solution. In a dose-response experiment the tumour and subcutaneous vascular beds seemed to be equally sensitive to noradrenaline. Isoprenaline did not influence the blood flow in either subcutaneous tissue or tumour, while papaverine increased subcutaneous tissue blood flow significantly but did not influence tumour blood flow. The results of the present blood flow studies might suggest that the tumour vascular bed is normally in a state close to maximal dilatation.
采用局部[133氙]清除技术，研究了包括去甲肾上腺素、异丙肾上腺素和罂粟碱在内的血管活性药物对可移植大鼠肉瘤局部血流及大鼠正常皮下组织血流的影响。通过透射电子显微镜（TEM）研究肿瘤的微血管床。通过TEM在肿瘤血管床中发现了具有一层收缩细胞的血管。在注入氙溶液中加入去甲肾上腺素后，肿瘤和正常皮下组织的血流均显著减少。在剂量反应实验中，肿瘤和皮下血管床对去甲肾上腺素似乎同样敏感。异丙肾上腺素对皮下组织或肿瘤的血流均无影响，而罂粟碱可显著增加皮下组织血流，但不影响肿瘤血流。目前血流研究的结果可能表明，肿瘤血管床通常处于接近最大扩张的状态。
