胃癌、结直肠癌和肾癌的促凝血活性依赖于凝血因子VII。
Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent.
作者信息
Szczepański M, Bardadin K, Zawadzki J, Pypno W
机构信息
Department of Biochemistry, Medical Center of Postgraduate Education, Warsaw, Poland.
出版信息
J Cancer Res Clin Oncol. 1988;114(5):519-22. doi: 10.1007/BF00391504.
Abstract
The PA of GC, CC, and RC extracts was assayed by the recalcification of human normal or F VII-DP, and the PA of normal tissue was also determined. The PA of normal tissue was higher than that of the cancer tissues in all groups of specimens. Substitution of normal plasma by F VII-DP resulted in significant depression of the PA and the differences in the PA between the normal and cancer tissue samples disappeared. Preincubation of normal and cancer tissue extracts with the cysteine proteinase inhibitors, mercuric chloride and iodoacetamide, did not affect the PA of these extracts. We conclude that the PA of the investigated cancer extracts is factor VII-dependent and can be related to the presence of tissue factor within cancer tissue.
摘要
通过对人正常血浆或F VII - DP进行再钙化来测定GC、CC和RC提取物的纤溶酶原激活物（PA），同时也测定正常组织的PA。在所有标本组中，正常组织的PA均高于癌组织。用F VII - DP替代正常血浆导致PA显著降低，正常组织和癌组织样本之间PA的差异消失。用半胱氨酸蛋白酶抑制剂氯化汞和碘乙酰胺对正常组织和癌组织提取物进行预孵育，并不影响这些提取物的PA。我们得出结论，所研究的癌提取物的PA依赖于因子VII，并且可能与癌组织中组织因子的存在有关。
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