Gelister J S, Mahmoud M, Lewin M R, Gaffney P J, Boulos P B
Br Med J (Clin Res Ed). 1986 Sep 20;293(6549):728-31. doi: 10.1136/bmj.293.6549.728.
A crucial step in the transition from adenomatous polyp to invasive colorectal cancer is the degradation of the epithelial basement membrane. Plasminogen activators may play a part in regulating the extracellular protease environment necessary for this to occur. Both functional and antigenic activity of the two principal activators of plasminogen, tissue plasminogen activator and urokinase, were measured in 30 colorectal cancers, matched samples of mucosa, and eight adenomatous polyps. Both polyps (p less than 0.01) and carcinomas (p less than 0.001) had raised urokinase activities compared with normal mucosa, the activity being highest in the carcinomas. Activity of tissue plasminogen activator, however, was diminished in both polyps (p less than 0.01) and carcinomas (p less than 0.001) compared with normal mucosa, the values being lowest in carcinomas. Plasmin generation by urokinase--in contrast with tissue plasminogen activator--is fibrin independent and thus less subject to physiological control.
从腺瘤性息肉转变为浸润性结直肠癌的关键步骤是上皮基底膜的降解。纤溶酶原激活剂可能参与调节发生这种情况所需的细胞外蛋白酶环境。在30例结直肠癌、匹配的黏膜样本和8例腺瘤性息肉中，对纤溶酶原的两种主要激活剂，即组织纤溶酶原激活剂和尿激酶的功能及抗原活性进行了测定。与正常黏膜相比，息肉（p<0.01）和癌（p<0.001）的尿激酶活性均升高，癌中的活性最高。然而，与正常黏膜相比，息肉（p<0.01）和癌（p<0.001）中的组织纤溶酶原激活剂活性均降低，癌中的值最低。与组织纤溶酶原激活剂不同，尿激酶产生纤溶酶不依赖于纤维蛋白，因此较少受生理控制。
