Guillot J P, Gonnet J F, Clement C, Caillard L, Truhaut R
Food Chem Toxicol. 1982 Oct;20(5):563-72. doi: 10.1016/s0278-6915(82)80065-3.
The primary cutaneous irritation of 56 chemicals was tested in the rabbit using three different procedures. The three protocols selected for the tests were the method published by the French authorities for the testing of cosmetics and toiletries (Journal Officiel 21 April 1973, p. 3862; ibid 5 June 1973, p. 3953) and the methods proposed for the testing of chemicals by the Association Française de Normalisation (AFNOR) and, in 1979, by the Organisation for Economic Co-operation and Development. The results of the three sets of tests were compared and the effects of differences in procedure and numbers of animals were studied, together with the possible relation between irritancy and the pH of the test material. It was concluded that the AFNOR protocol best met the requirements for such tests and that gloves should be worn for the handling of all substances classified as moderately or severely irritant on that scale.
采用三种不同方法在兔身上测试了56种化学物质的原发性皮肤刺激性。所选用于测试的三种方案分别是法国当局发布的化妆品和洗漱用品测试方法（《政府公报》1973年4月21日，第3862页；同上，1973年6月5日，第3953页），以及法国标准化协会（AFNOR）和经济合作与发展组织于1979年提出的化学物质测试方法。比较了三组测试的结果，研究了测试方法和动物数量差异的影响，以及刺激性与测试材料pH值之间的可能关系。得出的结论是，AFNOR方案最符合此类测试的要求，对于按该标准分类为中度或重度刺激性的所有物质，处理时应戴手套。
