Haddad N, Bechelli L M, Kwapinski J B, Simão E T
Int J Lepr Other Mycobact Dis. 1982 Sep;50(3):325-9.
Two hundred forty-four children between six months and 59 months of age from nursery schools and playgrounds in Ribeirão Preto, São Paulo, Brazil, were randomly allocated into five groups. These received: 1) intradermal BCG; 2) placebo; 3) antigen F, containing soluble cytoplasmic components of the mycobacteria Mycobacterium tuberculosis, M. aquae, and M. lepraemurium; 4) antigen G, containing soluble cytoplasmic components of M. piscium, and M. balnei, and 5) antigen H, containing soluble cytoplasmic components of M. leprae. BCG preinjected children had the highest proportion of positive late lepromin reactions. The injection of antigens F, G, or H had no effect on the late lepromin reactions. These findings contrasted with those observed in our earlier trial in which the injection of antigens X (containing soluble cytoplasmic components of the mycobacteria M. avium and M. gallinarum), Y (M. simiae, M. gallinarum, and M. avium), and Z (M. leprae, M. simiae, and M. borstelense) had caused significantly lower positive late lepromin reactions. By comparing the data of the present investigation with the findings of the first trial, it appears that the antigens obtained from M. borstelense and from either M. avium or M. gallinarum could have been instrumental in the impairment of lepromin activity observed in the first trial.
来自巴西圣保罗州里贝朗普雷图市托儿所和操场的244名6个月至59个月大的儿童被随机分为五组。这些组接受：1）皮内注射卡介苗；2）安慰剂；3）抗原F，包含结核分枝杆菌、水生分枝杆菌和鼠麻风分枝杆菌的可溶性细胞质成分；4）抗原G，包含鱼分枝杆菌和浴分枝杆菌的可溶性细胞质成分；5）抗原H，包含麻风分枝杆菌的可溶性细胞质成分。预先注射卡介苗的儿童晚期麻风菌素反应阳性比例最高。注射抗原F、G或H对晚期麻风菌素反应没有影响。这些发现与我们早期试验中观察到的结果形成对比，在早期试验中，注射抗原X（包含鸟分枝杆菌和鸡分枝杆菌的可溶性细胞质成分）、Y（猿分枝杆菌、鸡分枝杆菌和鸟分枝杆菌）和Z（麻风分枝杆菌、猿分枝杆菌和博斯特尔分枝杆菌）导致晚期麻风菌素反应阳性率显著降低。通过将本次调查的数据与首次试验的结果进行比较，似乎从博斯特尔分枝杆菌以及鸟分枝杆菌或鸡分枝杆菌中获得的抗原可能是导致首次试验中观察到的麻风菌素活性受损的原因。
