Shida A
Hokkaido Igaku Zasshi. 1982 Jul;57(4):457-65.
The purpose of this study was to determine the role of genetic influence on the variability of pulmonary function tests in normal individuals. Thirty-one pairs of twins (20 monozygotes (MZ) and 11 dizygotes (DZ) of both sexes, ranging in age from 15 to 18 years, were tested. Degree of similarity in each parameter was compared between MZ pairs and DZ pairs by within-pair variance ratio (MWDZ/MWMZ). The within-pair variances of MZ were smaller than DZ with respect to FVC, FEV1/FVC, V50, V25, delta N2 and FRC. These parameters were corrected for height; again the within-pair variances of MZ were smaller than DZ with respect to all the parameters except for FRC. The results indicate that these parameters were at least partly determined by genetic factor. However the within-pair variance of FEV1, PF, CV/VC, Raw, Pao2, Paco2, pH, and [HCO3-] were not different between the two groups. To estimate the similarity within MZ pairs, among-pair to within-pair variance ratio (MAMZ/MWMZ) were used. All the parameters of pulmonary mechanics showed similarity within pairs. Arterial pH and Pao2 also disclosed a significant similarity within-pairs, but Paco2 and [HCO3-] did not.
本研究的目的是确定遗传影响在正常个体肺功能测试变异性中的作用。对31对双胞胎（20对同卵双胞胎（MZ）和11对异卵双胞胎（DZ），男女皆有，年龄在15至18岁之间）进行了测试。通过配对内方差比（MWDZ/MWMZ）比较了MZ对和DZ对中每个参数的相似程度。就用力肺活量（FVC）、第一秒用力呼气容积/用力肺活量（FEV1/FVC）、50%肺活量时的流速（V50）、25%肺活量时的流速（V25）、氮洗出率增量（delta N2）和功能残气量（FRC）而言，MZ的配对内方差小于DZ。这些参数根据身高进行了校正；再次比较发现，除FRC外，MZ在所有参数上的配对内方差均小于DZ。结果表明，这些参数至少部分由遗传因素决定。然而，两组之间第一秒用力呼气容积（FEV1）、峰值流速（PF）、闭合气量/肺活量（CV/VC）、气道阻力（Raw）、动脉血氧分压（Pao2）、动脉血二氧化碳分压（Paco2）、pH值和[碳酸氢根离子]（[HCO3-]）的配对内方差并无差异。为了估计MZ对之间的相似性，使用了组间与组内方差比（MAMZ/MWMZ）。肺力学的所有参数在配对内均显示出相似性。动脉pH值和Pao2在配对内也显示出显著相似性，但Paco2和[HCO3-]并非如此。
