Shiraishi T
Tokai J Exp Clin Med. 1982 Jul;7(4):457-65.
Perfusion of 2-deoxy-D-glucose (2-DG) into the IIIrd ventricle (i.c.v.) or intraperitoneal (i.p.) injections produced changes in feeding and other overt behavior, as well as indicative changes in electroencephalograms (EEG). Applications of 2-DG, either i.p. or i.c.v., induced hyperphagia within 4 hr which was then followed by hypophagia for at least 96 hr. EEGs evinced low frequency patterns during the lethargy and ataxia symptoms which were present after i.p. injection. After i.c.v. injections, the low frequency EEG during the lethargy and ataxia were not evident. Present results in connection with prior reports indicate that 2-DG has a long term bimodal effect on feeding which may be mediated through central neurons. Hypophagia after peripheral application of 2-DG appeared to be caused at least as much by concomitant traumatism as by effects on neural control of feeding.
向第三脑室注射（脑室内注射）2-脱氧-D-葡萄糖（2-DG）或腹腔内（腹腔注射）注射会引起进食及其他明显行为的变化，以及脑电图（EEG）的指示性变化。腹腔注射或脑室内注射2-DG均会在4小时内诱发食欲亢进，随后至少96小时出现食欲减退。腹腔注射后出现的嗜睡和共济失调症状期间，脑电图显示出低频模式。脑室内注射后，嗜睡和共济失调期间的低频脑电图不明显。结合先前报告的现有结果表明，2-DG对进食有长期的双峰效应，这可能是通过中枢神经元介导的。外周应用2-DG后的食欲减退似乎至少与伴随的创伤一样多地是由对进食神经控制的影响所引起的。
