De Simone C, Ferrari M, Meli D, Midiri G, Sorice F
Arzneimittelforschung. 1982;32(11):1485-8.
Experimental and clinical data appear to indicate that Intralipid--an emulsion of soya bean oil, glycerol and egg lecithin--which is usually employed to improve caloric intake of parenteral nutrition regimens, may compromise human host defence mechanisms and therefore expose patients to an increased incidence of infectious diseases. Since from a biochemical point of view it has been suggested that a possible way whereby the somewhat poor reputation of Intralipid--attributable to the liver damage and the persistent lipaemia which attend its use--might be improved is to give supplementary carnitine which acts as a rate-limiting factor in the removal of the fat emulsion from blood, we hypothesized that the addition of carnitine to Intralipid could also result in a improvement of the immune responses both "in vitro" and "in vivo". Our results lend some support to the hypothesis in favour of a metabolic basis for some of the immunosuppressive properties of Intralipid and justify the inclusion of L-carnitine in parenteral nutrition regimens which, by abrogating some co-factor limitation, improves the immune responses of the host.
实验和临床数据似乎表明，英脱利匹特（一种由大豆油、甘油和卵磷脂组成的乳剂）通常用于增加肠外营养方案的热量摄入，但可能会损害人体宿主防御机制，从而使患者面临传染病发病率增加的风险。从生化角度来看，有人提出，鉴于英脱利匹特因其使用时伴随的肝损伤和持续血脂异常而名声欠佳，一种可能改善其状况的方法是补充肉碱，肉碱在从血液中清除脂肪乳剂的过程中起限速因子的作用。我们据此推测，在英脱利匹特中添加肉碱也可能在“体外”和“体内”改善免疫反应。我们的结果为该假说提供了一些支持，该假说认为英脱利匹特的某些免疫抑制特性存在代谢基础，这也证明了在肠外营养方案中加入L-肉碱的合理性，通过消除一些辅助因子的限制，L-肉碱可改善宿主的免疫反应。
