De Simone C, Ferrari M, Lozzi A, Meli D, Ricca D, Sorice F
Acta Vitaminol Enzymol. 1982;4(1-2):135-40.
Vitamin A affects the antibody responses and may affect phagocytic function and properdin levels. Pyridoxine deficiency impairs nucleic acid synthesis and depresses antibody formation, delayed hypersensitivity reactions and the ability of phagocytes to kill bacteria. Pantothenic acid deficiency impairs antibody formation. Vitamin C deficiency increases the incidence of infection, primary by a negative influence on reparative processes. Deficiencies of other vitamins either have not been sufficiently studied or have a variable effect. Moreover, even substances which for their biosynthesis require an adequate vitamin supplementation may exert immunomodulatory influences. With this respect the authors report their results on the influence of L-carnitine on the immune system. L-carnitine increases the proliferative responses of both murine and human lymphocyte following mitogenic stimulation and increase polymorphonuclear chemotaxis. Furthermore, L-carnitine, even at minimal concentrations, neutralizes the lipid induced immunosuppression.
维生素A影响抗体反应，可能还会影响吞噬功能和备解素水平。维生素B6缺乏会损害核酸合成，抑制抗体形成、迟发型超敏反应以及吞噬细胞杀灭细菌的能力。泛酸缺乏会损害抗体形成。维生素C缺乏会增加感染发生率，主要是因为对修复过程产生负面影响。其他维生素的缺乏要么尚未得到充分研究，要么影响各异。此外，即使是那些生物合成需要充足维生素补充的物质，也可能发挥免疫调节作用。在这方面，作者报告了他们关于左旋肉碱对免疫系统影响的研究结果。左旋肉碱可增强丝裂原刺激后小鼠和人类淋巴细胞的增殖反应，并增强多形核白细胞的趋化性。此外，即使是最低浓度的左旋肉碱也能抵消脂质诱导的免疫抑制作用。
