慢性实验性苯和乙烯中毒后肺的超微结构变化

Ultrastructural changes in the lungs after chronic experimental intoxication with benzine and ethyline vapour.

作者信息

Przybyłowski J, Jonek J, Grzybek H, Podolecki A, Pachołek A

出版信息

Exp Pathol (Jena). 1978;15(4):231-3. doi: 10.1016/s0014-4908(78)80061-1.

Abstract

In the group of rabbits chronically intoxicated with petrol vapour slight changes in the dust cells of lungs in the form of cytoplasmic vacuolisation and accumulation of collagen almost completely disappeared 3 months after intoxication. Changes in animals intoxicated with ethyline were much more severe. Besides the accumulation of collagen, appearance of elastin areas, cytolysosomes, changes in the nucleus, widening of ergastoplasm, swelling and cristolysis of mitochondria were observed. Three months after intoxication the decrease of previously observed changes was noted.

摘要

在长期吸入汽油蒸气的兔组中，肺尘埃细胞的轻微变化，如细胞质空泡化和胶原蛋白积累，在中毒3个月后几乎完全消失。吸入乙烯中毒的动物变化更为严重。除了胶原蛋白积累外，还观察到弹性蛋白区域的出现、细胞溶酶体、细胞核变化、内质网增宽、线粒体肿胀和嵴溶解。中毒3个月后，之前观察到的变化有所减轻。