Lantz E, Andersson A
Graefes Arch Clin Exp Ophthalmol. 1982;219(6):263-7. doi: 10.1007/BF00231410.
The authors studied the release of fibrinolytic activators from in vitro cultures of human and animal cornea with the following main findings: (1) the epithelium is the main activator source; (2) the addition of tripeptide, salicylate, chloroquine and phorbolester to the culture medium increases the fibrinolytic activity of the cultures; (3) corticosteroids depress the fibrinolytic activity; (4) explants of human conjunctiva also release fibrinolytic activators. The pathophysiological role of this activator is unknown. Hypothetically, besides preventing fibrin deposition on the surface of the eye, this activator may also stimulate leucocyte migration, activate procollagenase, protect the endothelial pump, and regulate vascular permeability and angiogenesis in the cornea.
作者研究了人及动物角膜体外培养物中纤维蛋白溶解激活剂的释放情况，主要发现如下：（1）上皮细胞是主要的激活剂来源；（2）在培养基中添加三肽、水杨酸盐、氯喹和佛波酯可增加培养物的纤维蛋白溶解活性；（3）皮质类固醇会降低纤维蛋白溶解活性；（4）人结膜外植体也会释放纤维蛋白溶解激活剂。这种激活剂的病理生理作用尚不清楚。据推测，除了防止纤维蛋白沉积在眼表面外，这种激活剂还可能刺激白细胞迁移、激活原胶原酶、保护内皮泵，并调节角膜的血管通透性和血管生成。
