Dourish C T, Davis B A, Dyck L E, Jones R S, Boulton A A
Pharmacol Biochem Behav. 1982 Dec;17(6):1291-4. doi: 10.1016/0091-3057(82)90137-x.
We have used an animal model of aggression, the isolation syndrome in mice, to examine the possible role of the trace amines, beta-phenylethylamine (PEA), meta-tyramine (m-TA) and para-tyramine (p-TA) in aggressive behaviour. The brain, plasma and urinary levels of PEA, m-TA and p-TA, and their respective major acid metabolites, phenylacetic acid (PAA), meta-hydroxyphenylacetic acid (m-HPA) and para-hydroxyphenylacetic acid (p-HPA) were measured in isolated aggressive mice (after fighting), and in group housed controls. The urinary levels of PEA, m-TA, PAA, m-HPA and p-HPA, and the plasma levels of PAA and p-HPA were significantly lower in isolated aggressive mice. Similarly, the whole brain levels of PEA, p-TA, PAA and p-HPA tended to be reduced. In contrast, the brain levels of m-TA and m-HPA tended to increase. It should be noted, however, that the present procedure did not dissociate the stress and aggression components of the isolation syndrome, and, therefore, further experiments are required to determine whether the observed neurochemical changes are functionally related to increased aggression.
我们利用一种攻击性行为的动物模型——小鼠隔离综合征，来研究痕量胺、β-苯乙胺（PEA）、间酪胺（m-TA）和对酪胺（p-TA）在攻击性行为中可能发挥的作用。我们测定了隔离饲养的攻击性小鼠（打斗后）和群居对照小鼠大脑、血浆及尿液中PEA、m-TA和p-TA及其各自主要酸性代谢产物苯乙酸（PAA）、间羟基苯乙酸（m-HPA）和对羟基苯乙酸（p-HPA）的水平。隔离饲养的攻击性小鼠尿液中PEA、m-TA、PAA、m-HPA和p-HPA的水平，以及血浆中PAA和p-HPA的水平显著降低。同样，大脑中PEA、p-TA、PAA和p-HPA的水平也有降低趋势。相比之下，大脑中m-TA和m-HPA的水平有升高趋势。然而，应当指出的是，本实验程序并未区分隔离综合征中的应激和攻击成分，因此，需要进一步实验来确定所观察到的神经化学变化是否与攻击性增加存在功能关联。
