Davis B A, Yu P H, Boulton A A, Wormith J S, Addington D
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):529-35. doi: 10.1016/0278-5846(83)90021-0.
Correlative relationships were investigated between biogenic trace amines and histories of violence among offenders incarcerated in two federal penitentiaries. Plasma levels of unconjugated (U) and conjugated (C) trace acids (PAA, mHPA and pHPA) and platelet MAO activity to the substrates PE, TRYP and TA were assessed. A pilot study (N = 26) revealed a lower activity of MAO to TRYP among violent offenders. The factor analytically derived scale, Prison Disturbance, correlated with mHPA (U) .77 (p less than .001), mHPA(C) -.42 (p less than .05) and PAA (U) -.37 (p less than .10), controlling for time incarcerated. In the principal investigation (N = 103), PAA(C) (p less than .01), pHPA (U) (p less than .05) levels, and MAO activity to TRYP (p less than .05) were lower among violent offenders. Factor scores of biochemical activity produced even more significant results. However, when these results were cross validated with data from the pilot study, only minimal relationships were maintained.
研究了两所联邦监狱中被监禁罪犯体内生物源性痕量胺与暴力史之间的相关关系。评估了未结合（U）和结合（C）痕量酸（苯乙酸、间羟基苯乙酸和对羟基苯乙酸）的血浆水平以及血小板对底物PE、TRYP和TA的单胺氧化酶（MAO）活性。一项初步研究（N = 26）显示，暴力罪犯中MAO对TRYP的活性较低。经因子分析得出的量表“监狱骚乱”与间羟基苯乙酸（U）的相关系数为0.77（p < 0.001），与间羟基苯乙酸（C）的相关系数为 - 0.42（p < 0.05），与苯乙酸（U）的相关系数为 - 0.37（p < 0.10），并对监禁时间进行了控制。在主要研究（N = 103）中，暴力罪犯的苯乙酸（C）水平（p < 0.01）、对羟基苯乙酸（U）水平（p < 0.05）以及MAO对TRYP的活性（p < 0.05）较低。生化活性的因子得分产生了更显著的结果。然而，当这些结果与初步研究的数据进行交叉验证时，仅维持了极小的相关性。
