Oates P S, Morgan R G
Aust J Biol Sci. 1982;35(5):505-15. doi: 10.1071/bi9820505.
Pancreatic secretion was studied in rats fed raw soyafour before (basal) and after stimulation with cholecystokinin-pancreozymin (CCK) given in either ascending or descending dose orders ranging from 1.25 to 20 or from 20 to 1.25 Crick-Harper-Raper units (CHRU). These results were compared with those reported previously for animals fed a stock cube diet. Two experimental conditions were used: anaesthetized animals were tested immediately after cannulation of the pancreatic duct and conscious animals were tested 48 h after surgery. Basal flow was significantly increased in anaesthetized and conscious rats fed RSF compared with the respective animals fed cubes. Mean basal protein output was also increased, but this difference was not significant. The pancreatic response to the ascending and descending doses of CCK in anaesthetized rats fed RSF was linearly related to the log of the dose of CCK in both animals fed RSF and cubes, though the response to CCK was greater in the rats fed RSF. When ascending doses of CCK were given to conscious rats fed RSF, the protein output increased up to 10 CHRU of CCK but was inhibited by 20 CHRU of CCK, whereas it decreased after the first dose of CCK (1.25 CHRU) in animals fed cubes. When descending doses of CCK were given to animals fed RSF, protein output was greatest after the first dose and no simple relationship between dose and response was seen. Compared with rats fed cubes, the pancreas in rats fed RSF thus appears to respond to a given dose of CCK with increased secretion, and conscious animals fed RSF can tolerate a higher dose of CCK before protein output is inhibited. This is consistent with an increased population of acinar cells in the animals fed RSF, with each hypertrophied cell responding to CCK with increased secretion.
研究了给大鼠喂食生大豆粉前后（基础状态），以及用胆囊收缩素-促胰酶素（CCK）以1.25至20或20至1.25克里克-哈珀-拉珀单位（CHRU）的递增或递减剂量顺序刺激后的胰腺分泌情况。将这些结果与先前报道的喂食块状饲料动物的结果进行了比较。使用了两种实验条件：麻醉动物在胰管插管后立即进行测试，清醒动物在手术后48小时进行测试。与喂食块状饲料的相应动物相比，喂食生大豆粉的麻醉和清醒大鼠的基础流量显著增加。平均基础蛋白质输出也有所增加，但这种差异不显著。在喂食生大豆粉的麻醉大鼠中，对递增和递减剂量CCK的胰腺反应与喂食生大豆粉和块状饲料的动物中CCK剂量的对数呈线性相关，尽管喂食生大豆粉的大鼠对CCK的反应更大。当给喂食生大豆粉的清醒大鼠给予递增剂量的CCK时，蛋白质输出在CCK达到10 CHRU时增加，但在20 CHRU的CCK时受到抑制，而在喂食块状饲料的动物中，在第一剂CCK（1.25 CHRU）后蛋白质输出就下降了。当给喂食生大豆粉的动物给予递减剂量的CCK时，蛋白质输出在第一剂后最大，且未观察到剂量与反应之间的简单关系。与喂食块状饲料的大鼠相比，喂食生大豆粉的大鼠的胰腺似乎对给定剂量的CCK反应时分泌增加，并且喂食生大豆粉的清醒动物在蛋白质输出受到抑制之前可以耐受更高剂量的CCK。这与喂食生大豆粉的动物中腺泡细胞数量增加一致，每个肥大的细胞对CCK的反应是分泌增加。
