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香菇菌丝体培养基中水溶性和醇不溶性组分的抗癌作用。

Anticarcinogenic actions of water-soluble and alcohol-insoluble fractions from culture medium of Lentinus edodes mycelia.

作者信息

Sugano N, Hibino Y, Choji Y, Maeda H

出版信息

Cancer Lett. 1982 Nov-Dec;17(2):109-14. doi: 10.1016/0304-3835(82)90022-2.

DOI:10.1016/0304-3835(82)90022-2
PMID:6891904
Abstract

The water-soluble (LEM) and alcohol-insoluble (LAP and LAP1) fractions were prepared from the culture medium of Lentinus edodes mycelia which was composed of bagasse and rice bran. LEM suppressed rat hepatocarcinogenesis and its cell proliferation of rat-ascites hepatoma to about 50% or less of each control group. LAP also suppressed cell proliferation at almost the same rate. LAP1 induced many small cells in the ascites and significantly raised the survival rate of hepatoma-bearing rats. Thus, anticarcinogenic action was revealed in LAP or LAP1 fractions which were mainly composed of xylose-containing polysaccharide and protein.

摘要

水溶性（LEM）和醇不溶性（LAP和LAP1）组分是从由甘蔗渣和米糠组成的香菇菌丝体培养基中制备的。LEM抑制大鼠肝癌发生及其对大鼠腹水肝癌细胞增殖的抑制作用约为各对照组的50%或更低。LAP也以几乎相同的速率抑制细胞增殖。LAP1在腹水中诱导产生许多小细胞，并显著提高荷肝癌大鼠的存活率。因此，在主要由含木糖的多糖和蛋白质组成的LAP或LAP1组分中发现了抗癌作用。

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Anticarcinogenic actions of water-soluble and alcohol-insoluble fractions from culture medium of Lentinus edodes mycelia.香菇菌丝体培养基中水溶性和醇不溶性组分的抗癌作用。
Cancer Lett. 1982 Nov-Dec;17(2):109-14. doi: 10.1016/0304-3835(82)90022-2.
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