Nomoto K, Yokokura T, Satoh H, Mutai M
Gan To Kagaku Ryoho. 1983 Mar;10(3):781-5.
The antitumor activity of a water-soluble substance extracted from Chlorella regulararis S-50, PCM-4, against murine transplanted tumors was investigated. PCM-4 is composed of sugar (25.7%), protein (51.5%) and nucleic acid (18.7%). By oral administration of PCM-4, both the growth of Sarcoma 180 and Meth A, subcutaneously implanted into mice, and ascites hepatoma AH 44 and AH 41C, intravenously implanted into rat, was inhibited. PCM-4 also showed antitumor activity against Sarcoma 180 and Meth A by intraperitoneal administration. The finding that PCM-4 has no direct growth-inhibition effect on tumor cells in vitro suggests that the antitumor activity of PCM-4 be elicited from the host-mediated response system.
对从普通小球藻S-50中提取的一种水溶性物质PCM-4针对小鼠移植肿瘤的抗肿瘤活性进行了研究。PCM-4由糖（25.7%）、蛋白质（51.5%）和核酸（18.7%）组成。通过口服PCM-4，皮下植入小鼠的肉瘤180和Meth A的生长，以及静脉植入大鼠的腹水肝癌AH 44和AH 41C的生长均受到抑制。PCM-4通过腹腔注射对肉瘤180和Meth A也显示出抗肿瘤活性。PCM-4在体外对肿瘤细胞没有直接生长抑制作用这一发现表明，PCM-4的抗肿瘤活性是由宿主介导的反应系统引发的。
