Katoh T, Ishige H, Takamizawa H, Tokita H, Tanaka N
Gan To Kagaku Ryoho. 1982 May;9(5):843-8.
The effects of various anticancer agents on human choriocarcinoma transplanted to nude mice, specifically, inhibition effects on tumor growth and survival rate were studied to establish an appropriate chemotherapy for refractory choriocarcinoma. The agents studied were methotrexate (MTX), actinomycin D (ACD), cyclophosphamide (CPM), vincristine (VCR), L-PAM (MPI), bleomycin (BLM), carboquone (CQ), cisplatin (CDDP), ACNU, MCNU, vinblastine (VLB), VP16-213, OK-432, Maruyama vaccine (SSM) and metronidazole (ME), and the following results were obtained: 1) The inhibition effects on tumor growth were obtained in the groups of VCR, VP16-213, CDDP, MPL, CPM and CQ; 2) The survival rate was 100% in the groups of MPL, BLM, and CQ. In the groups of ACD VLB, VP16-213 and VCR, all mice died. 3) MPL was found to be the most effective agent in terms of inhibitory effect and survival rate. In the future, combination chemotherapy including MPL and maintenance chemotherapy with MPL to refractory choriocarcinoma should be studied.
研究了各种抗癌药物对移植到裸鼠体内的人绒毛膜癌的影响，具体而言，研究了它们对肿瘤生长的抑制作用和存活率，以建立针对难治性绒毛膜癌的合适化疗方案。所研究的药物有甲氨蝶呤（MTX）、放线菌素D（ACD）、环磷酰胺（CPM）、长春新碱（VCR）、左旋苯丙氨酸氮芥（L-PAM，MPI）、博来霉素（BLM）、卡波醌（CQ）、顺铂（CDDP）、嘧啶亚硝脲（ACNU）、甲环亚硝脲（MCNU）、长春碱（VLB）、依托泊苷（VP16-213）、溶链菌制剂（OK-432）、丸山疫苗（SSM）和甲硝唑（ME），并得到以下结果：1）VCR、VP16-213、CDDP、MPL、CPM和CQ组对肿瘤生长有抑制作用；2）MPL、BLM和CQ组的存活率为100%。ACD、VLB、VP16-213和VCR组的所有小鼠均死亡。3）就抑制作用和存活率而言，MPL被发现是最有效的药物。未来，应研究包括MPL的联合化疗以及用MPL对难治性绒毛膜癌进行维持化疗。
