Katoh T, Ishige H, Kobayashi O, Takamizawa H, Tanaka N, Tokita H
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Dec;33(12):2055-64.
Serial transplantation in nude mice of human choriocarcinoma showed the drug resistance in clinic was succeeded and experimental chemotherapy has been studied to improve the prognosis of the patients with choriocarcinoma. The experimental tumors were two lines. CC-I-JCK (JCK) and CC-HM-I- (HM). In this paper, single and/or combination chemotherapy with methotrexate (MTX), actinomycin D (ACD), cyclophosphamide (CMP), and vincristine (VCR) were discussed. 1) Effects of the single agent: In JCK, the suppressive effects against tumor growth under administration of CPM or VCR, and some responses in histological finding were obtained. While, in HM, few suppressive effects against tumor growth and some responses in histological findings were obtained. 2) Effects of the combined agents: In JCK, the suppressive effects against tumor growth were as follows; nontreatment group less than MTX + ACD less than MTX + CPM less than MTX + ACD + CPM less than ACD + CPM less than ACD + CPM + VCR. The complete disappearance of tumors were gained under administration of the combination therapy with ACD and CPM. While in in HM, the effects were as follows; nontreatment group less than MTX + ACD less than ACD + CPM less than MTX + ACD + CPM less than MTX + CPM less than MTX + CPM + VRC. But no complete disappearance of tumor was obtained. 3) The good relationship between the results of experimental chemotherapy and the response of clinical patients who provided the tissues could be seen. It has been defined that the experimental chemotherapy with the tumors transplanted to nude mice in useful models for the establishment of rational chemotherapy for drug resistant choriocarcinoma.
人绒毛膜癌在裸鼠中的连续移植表明临床耐药成功，并且已经开展了实验性化疗以改善绒毛膜癌患者的预后。实验性肿瘤有两条细胞系，CC-I-JCK（JCK）和CC-HM-I-（HM）。本文讨论了甲氨蝶呤（MTX）、放线菌素D（ACD）、环磷酰胺（CMP）和长春新碱（VCR）的单药及联合化疗。1）单药效果：在JCK中，给予CMP或VCR时对肿瘤生长有抑制作用，并且在组织学检查中有一些反应。而在HM中，对肿瘤生长的抑制作用很少，在组织学检查中有一些反应。2）联合用药效果：在JCK中，对肿瘤生长的抑制作用如下；未治疗组＜MTX+ACD＜MTX+CMP＜MTX+ACD+CMP＜ACD+CMP＜ACD+CMP+VCR。给予ACD和CMP联合治疗时肿瘤完全消失。而在HM中，效果如下；未治疗组＜MTX+ACD＜ACD+CMP＜MTX+ACD+CMP＜MTX+CMP＜MTX+CMP+VRC。但未获得肿瘤完全消失的情况。3）可以看到实验性化疗结果与提供组织的临床患者反应之间有良好的相关性。已经确定，将肿瘤移植到裸鼠中的实验性化疗是建立耐药性绒毛膜癌合理化疗的有用模型。
