Katoh T, Ishige H, Kobayashi O, Takamizawa H, Tokita H, Tanaka N
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Feb;34(2):173-9.
Experimental chemotherapy has been studying with choriocarcinoma in nude mice transplanted from drug resistant patients. The following results: 1) the combined therapy with MTX and ACD was not always effective and in place of one of them, the combination of CPM was effective 2) addition of VCR was effective; were obtained. These results were applied to two patients in clinic. 1) The first patient failed to obtain complete remission by the course of ACD, MTX + ACD, and MTX + ACD + CPM (MAC) therapy. Then the combination therapy with ACD + CPM made her HCG titer regressed to negative immediately. She is free from disease now. 2) The HCG titer and pulmonary metastasis of the second patient showed resistance to MAC therapy, CHAMOMA therapy, and the combined therapy with MTX. The combination chemotherapy with ACD + CPM + VCR made her HCG titer become to regressed and the pulmonary metastasis reduce to 1/4 in size. The clinical application of the results from experimental chemotherapy was defined to be possible. The experimental model will contribute to establish the schedule of the rational chemotherapy for drug-resistant choriocarcinoma.
已经在用耐药患者移植的裸鼠中的绒毛膜癌进行实验性化疗研究。获得了以下结果：1）甲氨蝶呤（MTX）和放线菌素D（ACD）的联合治疗并非总是有效，用环磷酰胺（CPM）替代其中之一的联合治疗是有效的；2）添加长春新碱（VCR）是有效的。这些结果应用于两名临床患者。1）第一名患者在接受放线菌素D、甲氨蝶呤+放线菌素D以及甲氨蝶呤+放线菌素D+环磷酰胺（MAC）治疗过程中未能获得完全缓解。然后，放线菌素D+环磷酰胺的联合治疗使她的人绒毛膜促性腺激素（HCG）滴度立即降至阴性。她现在已无疾病。2）第二名患者的HCG滴度和肺转移对MAC治疗、CHAMOMA治疗以及甲氨蝶呤联合治疗均表现出耐药。放线菌素D+环磷酰胺+长春新碱的联合化疗使她的HCG滴度下降，肺转移灶大小缩小至原来的1/4。实验性化疗结果的临床应用被确定为可行。该实验模型将有助于制定耐药绒毛膜癌的合理化疗方案。
