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本文引用的文献

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VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.免疫应答过程中抗体亲和力的变化
Biochemistry. 1964 Jul;3:996-1008. doi: 10.1021/bi00895a027.
2
The influence of the A-like substance of rabbits on their immune response to human blood-group A-substance.兔的A类物质对其针对人血型A物质免疫反应的影响。
J Immunol. 1956 May;76(5):357-62.
3
Influenza: the new acquayantance.流感：新相识。 （注：原文中“acquayantance”拼写有误，正确拼写应为“acquaintance” ）
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Immunological tolerance as the result of terminal differentiation of immunologically competent cells.免疫耐受是免疫活性细胞终末分化的结果。
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Single lymph node cells producing heteroclitic bacteriophage antibody.产生特异性交叉反应噬菌体抗体的单个淋巴结细胞。
J Immunol. 1965 Aug;95(2):378-86.
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The dosage requirements for immunological paralysis by soluble proteins.可溶性蛋白质导致免疫麻痹的剂量要求。
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Increase and decrease in binding affinity of antibodies during the immune response.免疫反应过程中抗体结合亲和力的增加与降低。
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8
Cell selection by antigen in the immune response.免疫应答中抗原介导的细胞选择。
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9
Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol.通过聚乙二醇沉淀法检测抗体和可溶性抗原-抗体复合物。
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10
Studies on canine secretory alloantigens (CSA).犬分泌型同种异体抗原（CSA）的研究。
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A 型和 A+型兔子免疫反应成熟度的差异。分别是 A 抗原的良好应答者和不良应答者。

Differences in the maturation of the immune response of A- and A+ rabbits. Good and poor responders respectively for the A antigen.

作者信息

Oriol R, Dalix A M

出版信息

Immunology. 1977 Jul;33(1):91-9.

PMID:68927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445406/
Abstract

The amount, avidity and specificity of anti-A antibodies produced by rabbits having the A substance in their secretions (A+) and rabbits lacking this antigen (A-), were studied with a series of antigens chemically related to the A substance. Both A- and A+ rabbits produced specific anti-A antibodies but the amount, maturation of avidity and specificity of these antibodies was completely different. These results suggest that the difference between the immune response of A+ and A- animals is not based on a genetically determined inability of A+ rabbits to recognize the self antigen, but rather on differences in the regulatory mechanism(s) controlling the maturation process of the anti-A response.

摘要

对分泌液中含有A物质的兔子（A+）和缺乏该抗原的兔子（A-）所产生的抗A抗体的量、亲和力和特异性，用一系列与A物质化学相关的抗原进行了研究。A-和A+兔子均产生了特异性抗A抗体，但这些抗体的量、亲和力成熟度和特异性却完全不同。这些结果表明，A+和A-动物免疫反应的差异并非基于A+兔子在基因上无法识别自身抗原，而是基于控制抗A反应成熟过程的调节机制存在差异。