Le Mesurier S M, Lykke A W, Stewart B W
Toxicol Lett. 1980 Jan;5(1):89-93. doi: 10.1016/0378-4274(80)90153-8.
Repeated exposure of rats to trichloroethylene, carbon tetrachloride, gasoline vapour or to cigarette smoke is followed by significant reduction in the recovery of pulmonary surfactant, inhibition being evident as early as 5 days after commencement of treatment. The degree of reduction in surfactant recovery was dose-dependent and the kinetics of this reaction indicated the relative toxicities of the treatments. The results are discussed with reference to the use of surfactant recovery as an indicator of non-specific injury to respiratory tissue.
大鼠反复接触三氯乙烯、四氯化碳、汽油蒸气或香烟烟雾后，肺表面活性物质的恢复会显著降低，早在治疗开始5天后抑制作用就很明显。表面活性物质恢复的降低程度呈剂量依赖性，该反应的动力学表明了各治疗方法的相对毒性。结合使用表面活性物质恢复作为呼吸组织非特异性损伤指标的情况对结果进行了讨论。
