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抗骨骼肌肌动蛋白抗体及其与脉络膜恶性黑色素瘤的反应性。

Antibodies to skeletal muscle actin and their reactivity with malignant melanoma of the choroid.

作者信息

Malaty A, Rahi A, Garner A

出版信息

Br J Ophthalmol. 1980 Mar;64(3):181-5. doi: 10.1136/bjo.64.3.181.

DOI:10.1136/bjo.64.3.181
PMID:6892991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1039384/
Abstract

Imprints of choroidal malignant melanoma cells were treated with serum containing antibodies to a purified preparation of actin derived from skeletal muscle. Evidence of a positive reaction, as shown by indirect immunofluorescence, substantiated an impression based on morphological criteria that choroidal melanoma cells contain actin protein. The significance of this protein in tumour biology is discussed, and a possible interference by antiactin antibodies in the immunodiagnosis of choroidal melanoma is highlighted.

摘要

脉络膜恶性黑色素瘤细胞印记用含有针对从骨骼肌提取的纯化肌动蛋白制剂抗体的血清处理。间接免疫荧光显示的阳性反应证据证实了基于形态学标准的一种印象，即脉络膜黑色素瘤细胞含有肌动蛋白。文中讨论了这种蛋白质在肿瘤生物学中的意义，并强调了抗肌动蛋白抗体在脉络膜黑色素瘤免疫诊断中可能产生的干扰。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/585f/1039384/0784360e93c9/brjopthal00195-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/585f/1039384/36f22f572c1d/brjopthal00195-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/585f/1039384/facb1b3f8fb8/brjopthal00195-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/585f/1039384/0784360e93c9/brjopthal00195-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/585f/1039384/36f22f572c1d/brjopthal00195-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/585f/1039384/facb1b3f8fb8/brjopthal00195-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/585f/1039384/0784360e93c9/brjopthal00195-0040-a.jpg

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Antibodies to skeletal muscle actin and their reactivity with malignant melanoma of the choroid.抗骨骼肌肌动蛋白抗体及其与脉络膜恶性黑色素瘤的反应性。
Br J Ophthalmol. 1980 Mar;64(3):181-5. doi: 10.1136/bjo.64.3.181.
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引用本文的文献

1
Early diagnosis of choroidal melanoma.脉络膜黑色素瘤的早期诊断
Br J Ophthalmol. 1980 Mar;64(3):146-7. doi: 10.1136/bjo.64.3.146.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
THE RELATIVE AFFINITIES OF NUCLEOTIDES TO G-ACTIN AND THEIR EFFECTS.核苷酸与G-肌动蛋白的相对亲和力及其影响
Biochim Biophys Acta. 1964 Jun 8;86:543-53. doi: 10.1016/0304-4165(64)90094-7.
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The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
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Autoantibodies and the hepatitis-associated antigen in acute infective hepatitis.急性感染性肝炎中的自身抗体与肝炎相关抗原
Br Med J. 1970 Jun 20;2(5711):693-5. doi: 10.1136/bmj.2.5711.693.
6
Smooth muscle antibody in malignant disease.恶性疾病中的平滑肌抗体。
Br Med J. 1971 Nov 27;4(5786):511-3. doi: 10.1136/bmj.4.5786.511.
7
Reaction of human smooth muscle antibody with liver cells.人平滑肌抗体与肝细胞的反应。
Nat New Biol. 1971 Aug 11;232(2):186-7. doi: 10.1038/newbio232186a0.
8
Reaction of human smooth muscle antibody with thyroid cells.人平滑肌抗体与甲状腺细胞的反应。
Clin Exp Immunol. 1974 Nov;18(3):371-7.
9
The occurrence of autoantibodies in infectious mononucleosis.传染性单核细胞增多症中自身抗体的出现。
Clin Exp Immunol. 1974 Jul;17(3):427-36.
10
Immunofluorescent tracing of smooth muscle contractile protein antigens in tissues other than smooth muscle.平滑肌收缩蛋白抗原在平滑肌以外组织中的免疫荧光追踪
Clin Exp Immunol. 1974 Jan;16(1):125-35.