膜（M）蛋白对甲型流感病毒病毒粒子体外转录酶活性及其对金刚乙胺敏感性的影响。
Influence of membrane (M) protein on influenza A virus virion transcriptase activity in vitro and its susceptibility to rimantadine.
作者信息
Zvonarjev A Y, Ghendon Y Z
出版信息
J Virol. 1980 Feb;33(2):583-6. doi: 10.1128/JVI.33.2.583-586.1980.
Abstract
The transcriptase activity of influenza A virus ribonucleoproteins was inhibited by 42 to 49% in vitro in the presence of membrane (M) protein. The addition of M protein to the system of ribonucleoprotein preparations isolated from rimantadine-sensitive or rimantadine-resistant influenza virus strains, as well as the addition of M protein isolated from a sensitive strain, in the presence of rimantadine further inhibited the transcriptase activity of such complexes by approximately 40%. In the system containing the same ribonucleoprotein preparations, but with M protein isolated from a rimantadine-resistant influenza virus strain, the transcriptase activity was not sensitive to rimantadine. The data show that M protein can influence the activity of influenza A virus virion transcriptase and that the susceptibility of influenza virus to rimantadine may be due to the peculiarities of M protein.
摘要
在存在膜（M）蛋白的情况下，甲型流感病毒核糖核蛋白的转录酶活性在体外被抑制了42%至49%。将M蛋白添加到从对金刚烷胺敏感或耐药的流感病毒株中分离出的核糖核蛋白制备体系中，以及在存在金刚烷胺的情况下添加从敏感株中分离出的M蛋白，会使此类复合物的转录酶活性进一步被抑制约40%。在含有相同核糖核蛋白制备物但使用从耐药流感病毒株中分离出的M蛋白的体系中，转录酶活性对金刚烷胺不敏感。数据表明，M蛋白可影响甲型流感病毒病毒粒子转录酶的活性，且流感病毒对金刚烷胺的敏感性可能归因于M蛋白的特性。
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Influence of membrane (M) protein on influenza A virus virion transcriptase activity in vitro and its susceptibility to rimantadine.膜（M）蛋白对甲型流感病毒病毒粒子体外转录酶活性及其对金刚乙胺敏感性的影响。
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