[用哌仑西平预防应激性溃疡——一项对照研究]
[Stress-ulcer prevention with pirenzepine-a controlled study].
作者信息
Mattes P, Peros G, Belohlavek D, Malfertheiner P, Herfarth C
出版信息
Z Gastroenterol. 1980 Jun;18(6):325-7.
PMID:6893379
Abstract
In polytraumatised or septic patients without adequate medical prophylaxis the incidence-rate of postoperative complications is very high. The incidence-rate of acute mucosal stress lesions is to be expected 100 per cent. The parenteral application of pirenzepine shows in comparison to placebo a clear protective effect measured as incidence-rate of stress lesion (p greater than 0,05) and occurrence of bleeding (p greater than 0,01).
摘要
在没有充分医学预防措施的多发伤或脓毒症患者中，术后并发症的发生率非常高。急性黏膜应激性病变的发生率预计为100%。与安慰剂相比，静脉注射哌仑西平在应激性病变发生率（p>0.05）和出血发生率（p>0.01）方面显示出明显的保护作用。
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引用本文的文献
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Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases.哌仑西平。其药效学和药代动力学特性以及在消化性溃疡疾病和其他相关疾病中的治疗效果综述。
Drugs. 1985 Aug;30(2):85-126. doi: 10.2165/00003495-198530020-00001.
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